Module CC-29 · Version 1.0
Pharmacogenomics for the Laboratory Professional
Follow a pharmacogenomic result from a detected variant through diplotype and predicted phenotype to a bounded, current report.
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Who this module is for
Medical laboratory professionals who support validated pharmacogenomic testing and reporting.
Learning objectives
- Distinguish genotype, diplotype, star allele, phenotype, and clinical recommendation layers.
- Recognize copy-number, structural-variant, ancestry, phasing, and no-call limitations.
- Explain that CPIC-style guidance addresses how to use an existing result, not whether a patient must be tested.
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
14 sources
1. Clinical Pharmacogenetics Implementation Consortium. CYP2D6 Genotype and Use of 5-HT3 Receptor Antagonists: 2026 Update.
Source note · professional society guidance
2. Lee CR, et al. CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update. Clin Pharmacol Ther. 2022;112:959-967.
Source note · professional society guidance
3. Pratt VM, et al. Recommendations for Clinical CYP2D6 Genotyping Allele Selection. J Mol Diagn. 2021;23:1047-1064.
Source note · consensus standard
4. PharmVar. Structural Variation, CYP2D6 gene-support document.
Source note · consensus standard
5. US FDA. Table of Pharmacogenomic Biomarkers in Drug Labeling.
Source note · federal guidance
6. US FDA. Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers.
Source note · federal guidance
7. eCFR. 42 CFR 493.1232, Standard: Specimen submission, handling, and referral.
Source note · federal regulation
8. eCFR. 42 CFR 493.1291, Standard: Test report.
Source note · federal regulation
9. CMS. State Operations Manual, Appendix C, CLIA laboratory interpretive guidance.
Source note · federal regulation
10. eCFR. 42 CFR 493.1449, Standard: Technical supervisor qualifications.
Source note · federal regulation
11. Clinical Pharmacogenetics Implementation Consortium. CPIC guidelines for translating pharmacogenetic test results into clinical practice.
Source note · professional society guidance
12. Cicali EJ, et al. How to Integrate CYP2D6 Phenoconversion into Clinical Pharmacogenetics: A Tutorial. Clin Pharmacol Ther. 2021.
Source note · peer-reviewed literature
13. Association for Molecular Pathology. Best Practices for Pharmacogenomic Reporting (position statement).
Source note · professional society guidance
14. Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review. J Pers Med. 2021.
Source note · peer-reviewed literature