Module COAG-01 · Version 1.0
Primary Hemostasis: Vessels, Platelets, and the Initial Plug
Follow the initial platelet plug from vascular injury through aggregation, then use count, smear, and aggregometry observations to localize a quantitative, adhesion, or aggregation problem.
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Who this module is for
Medical laboratory science learners and laboratory professionals who use CBC, peripheral smear, and platelet-function observations in a hemostasis workup.
Learning objectives
- Describe the sequence from vascular injury to the primary platelet plug.
- Relate platelet count, size, morphology, and selected function tests to the sequence.
- Distinguish quantitative platelet problems from qualitative platelet or von Willebrand factor problems.
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
16 sources
1. 42 CFR §493.941, Standard: Hematology (including routine hematology and coagulation), Code of Federal Regulations, Title 42, Part 493, Subpart I.
Source note · federal regulation
2. 42 CFR §493.1269, Standard: Hematology, Code of Federal Regulations, Title 42, Part 493, Subpart K.
Source note · federal regulation
3. College of American Pathologists, Hematology and Coagulation Checklist, Laboratory Accreditation Program.
Source note · accreditation standard
4. CLSI H21, Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays, 6th ed., 2024.
Source note · consensus standard
5. CLSI H58-A, Platelet Function Testing by Aggregometry; Approved Guideline, 2008.
Source note · consensus standard
6. Cattaneo M, Cerletti C, Harrison P, et al. Recommendations for the standardization of light transmission aggregometry. J Thromb Haemost. 2013;11(6):1183-1189.
Source note · professional society guidance
7. Rodeghiero F, et al. Normal range of bleeding scores for the ISTH-BAT: adult and pediatric data from the merging project. Blood Transfus. 2014.
Source note · peer-reviewed literature
8. James PD, et al. ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease. Blood Adv. 2021;5(1):280-300.
Source note · professional society guidance
9. International Council for Standardization in Haematology / ISLH. Platelet counting by the RBC/platelet ratio method: a reference method. Am J Clin Pathol. 2001.
Source note · consensus standard
10. Physiological Haemostasis, in Mechanisms of Vascular Disease, NCBI Bookshelf NBK534253.
Source note · peer-reviewed literature
11. Platelet Adhesion to Vascular Walls, NCBI Bookshelf NBK53456.
Source note · peer-reviewed literature
12. Golebiewska EM, Poole AW. Platelet secretion: from haemostasis to wound healing and beyond. Blood Rev. 2015.
Source note · peer-reviewed literature
13. Multiple Functions of the Endothelial Cells, in The Endothelium, NCBI Bookshelf NBK57148.
Source note · peer-reviewed literature
14. Laboratory Evaluation of Coagulopathies, StatPearls, NCBI Bookshelf NBK606118.
Source note · peer-reviewed literature
15. Glanzmann Thrombasthenia, StatPearls, NCBI Bookshelf NBK538270.
Source note · peer-reviewed literature
16. Von Willebrand Disease, GeneReviews, NCBI Bookshelf NBK7014.
Source note · peer-reviewed literature