LatticeMLS
Menu

Module CC-15 · Version 1.0

Reading a Lipid Panel

Interpret a standard lipid panel by separating what the analyzer measures from what is calculated, verify the calculation behind LDL-C and non-HDL-C, and recognize when triglycerides are too high for a calculated LDL-C result to be reported.

Your next section

Start section 1

Read without an account. Sign in to save.

Who this module is for

Clinical laboratory scientists and students working in general chemistry who release or review lipid panel results

Learning objectives

  • Explain the roles of total cholesterol, HDL-C, triglycerides, LDL-C, non-HDL-C, and apolipoprotein B in a lipid panel
  • Identify which lipid panel results are measured and which are calculated, and state the main limitation of each calculation equation
  • Recognize how fasting status, severe hypertriglyceridemia, and specimen handling affect which lipid results can be reported

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

14 sources

  1. 1. Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. J Am Coll Cardiol. 2019;73(24):e285-e350.

    Source note · professional society guidance

  2. 2. Blumenthal RS, Morris PB, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia. J Am Coll Cardiol. Published online March 13, 2026.

    Source note · professional society guidance

  3. 3. Martin SS, Blaha MJ, Elshazly MB, et al. Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. JAMA. 2013;310(19):2061-2068.

    Source note · peer-reviewed literature

  4. 4. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502.

    Source note · peer-reviewed literature

  5. 5. Sampson M, Ling C, Sun Q, et al. A New Equation for Calculation of Low-Density Lipoprotein Cholesterol in Patients With Normolipidemia and/or Hypertriglyceridemia. JAMA Cardiol. 2020;5(5):540-548.

    Source note · peer-reviewed literature

  6. 6. Carroll MD, Rammon J, Storandt R, Tolliver EA. Comparing Low-density Lipoprotein Cholesterol Population Estimates Using Different Predictive Equations: NHANES 2015-2018. National Health Statistics Reports No. 220. NCHS; published online December 16, 2025.

    Source note · federal guidance

  7. 7. American Heart Association. "Apolipoprotein B." Professional/patient education page, heart.org.

    Source note · professional society guidance

  8. 8. Marcovina SM, et al. Reference Materials for the Standardization of the Apolipoproteins A-I and B, and Lipoprotein(a). PMC review article.

    Source note · peer-reviewed literature

  9. 9. CLSI. C56QG: Examples of Hemolyzed, Icteric, and Lipemic/Turbid Samples Quick Guide.

    Source note · consensus standard

  10. 10. CLSI. PRE04: Handling, Transport, Processing, and Storage of Blood Specimens for Routine Laboratory Examinations.

    Source note · consensus standard

  11. 11. CLSI. GP47: Management of Critical- and Significant-Risk Results.

    Source note · consensus standard

  12. 12. Centers for Medicare & Medicaid Services. 42 CFR 493.1255, Calibration and calibration verification (and CMS interpretive guidance, State Operations Manual Appendix C).

    Source note · federal regulation

  13. 13. College of American Pathologists. Chemistry and Toxicology Checklist, CHM.15225 eGFR and LDL Cholesterol Calculated Test Results (Phase I). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard

  14. 14. Roche Diagnostics. Triglycerides (TRIGL) assay method sheet / instructions for use.

    Source note · manufacturer labeling