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Module CC-30 · Version 1.0

Heavy Metals, Trace Elements, and Selected Toxins

Select contamination-controlled specimens and interpret trace-element results by matrix, timing, species, and analytical method.

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Who this module is for

Medical laboratory scientists and trainees working with trace-element and toxicology specimens.

Learning objectives

  • Match blood, urine, hair, or other matrices to the toxicological question.
  • Identify collection-device, skin, environment, reagent, and carryover contamination risks.
  • Distinguish total element concentration from chemical species and exposure from toxicity.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

20 sources

  1. 1. Clinical and Laboratory Standards Institute. C38: Control of Preexamination Variation in Trace Element Determinations, 2nd ed. CLSI; 2024.

    Source note · consensus standard

  2. 2. Clinical and Laboratory Standards Institute. C40: Measurement Procedures for the Determination of Lead in Whole Blood, 3rd ed. CLSI; 2024.

    Source note · consensus standard

  3. 3. Clinical and Laboratory Standards Institute. C62: Liquid Chromatography-Mass Spectrometry Methods, 3rd ed. CLSI.

    Source note · consensus standard

  4. 4. Clinical and Laboratory Standards Institute. GP34: Validation and Verification of Tubes for Venous and Capillary Blood Specimen Collection.

    Source note · consensus standard

  5. 5. Ruckart PZ, et al. Update of the Blood Lead Reference Value, United States, 2021. MMWR. 2021;70:1509-1512.

    Source note · federal guidance

  6. 6. CDC. Recommended Actions Based on Blood Lead Level. Childhood Lead Poisoning Prevention.

    Source note · federal guidance

  7. 7. CDC. About the Data: Blood Lead Surveillance. Childhood Lead Poisoning Prevention.

    Source note · federal guidance

  8. 8. 42 CFR 493.1291, Standard: Test report, current e-CFR text.

    Source note · federal regulation

  9. 9. Agency for Toxic Substances and Disease Registry. Clinician Brief: Arsenic.

    Source note · federal guidance

  10. 10. CDC/NCHS. Arsenic Species in Urine, Laboratory Procedure Manual, NHANES 2011-2012.

    Source note · federal guidance

  11. 11. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury: Toxicokinetics.

    Source note · federal guidance

  12. 12. Agency for Toxic Substances and Disease Registry. Toxicological Profile for Mercury, Health Effects section.

    Source note · federal guidance

  13. 13. CDC/ATSDR. Evaluating Mercury Exposure: Information for Health Care Providers.

    Source note · federal guidance

  14. 14. CDC. Guidance for Laboratory Biomonitoring Programs.

    Source note · federal guidance

  15. 15. ACGIH. 2024 TLVs and BEIs: Biological Exposure Indices.

    Source note · professional society guidance

  16. 16. Mayo Clinic Laboratories. Trace Metals Analysis: Specimen Collection and Transport.

    Source note · laboratory reference

  17. 17. Labcorp. Test 085340: Cadmium, Whole Blood.

    Source note · laboratory reference

  18. 18. Peer-reviewed and applications literature on collision/reaction cell ICP-MS for clinical trace elements.

    Source note · peer-reviewed literature

  19. 19. Peer-reviewed literature on internal standard selection in ICP-MS.

    Source note · peer-reviewed literature

  20. 20. Manufacturer instructions for use for the laboratory's installed ICP-MS or GFAAS system, local controlled copy.

    Source note · manufacturer labeling