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Module COAG-11 · Version 1.0

Coagulation Cases: Putting the Entire Pattern Together

A capstone set of coagulation cases that requires the same reasoning sequence learned across prior coagulation modules: check the specimen and medication history first, build a ranked laboratory differential from the screening pattern, and choose the next test that most separates the leading explanations while preserving uncertainty.

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Who this module is for

Certified or in-training clinical laboratory scientists and residents who have completed the earlier coagulation modules and now need to integrate specimen quality, screening tests, mixing studies, factor assays, and platelet findings into one working sequence.

Learning objectives

  • Prioritize preanalytical and medication checks before advanced interpretation of a coagulation result
  • Construct and revise a ranked laboratory differential as new evidence appears
  • Choose next tests and communication steps while explicitly preserving uncertainty

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

14 sources

  1. 1. Clinical and Laboratory Standards Institute. H47, One-Stage Prothrombin Time Test and Activated Partial Thromboplastin Time Test, 3rd ed., 2023. https://clsi.org/shop/standards/h47/

    Source note · consensus standard

  2. 2. Clinical and Laboratory Standards Institute. H21, Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays, 6th ed., 2024. https://clsi.org/shop/standards/h21/

    Source note · consensus standard

  3. 3. College of American Pathologists. Hematology and Coagulation Checklist, current sample checklist. https://documents.cap.org/documents/cap-hem-sample-checklist.pdf

    Source note · accreditation standard

  4. 4. 42 CFR 493.1269, Standard: General quality control requirements. https://www.ecfr.gov/current/title-42/chapter-IV/subchapter-G/part-493/subpart-K/section-493.1269

    Source note · federal guidance

  5. 5. 42 CFR 493.1253, Standard: Establishment and verification of performance specifications. https://www.ecfr.gov/current/title-42/chapter-IV/subchapter-G/part-493/subpart-K/section-493.1253

    Source note · federal guidance

  6. 6. Devreese KMJ, et al. Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the ISTH. J Thromb Haemost. 2020;18:2828-2839. https://doi.org/10.1111/jth.15047

    Source note · professional society guidance

  7. 7. Meijer P, et al. International Council for Standardization in Haematology field study evaluating optimal interpretation methods for aPTT and PT mixing studies. Arch Pathol Lab Med. 2024;148:880-887. https://doi.org/10.5858/arpa.2023-0147-OA

    Source note · peer-reviewed literature

  8. 8. Kitchen S, et al. Diagnosis and Laboratory Monitoring of Hemophilia A and B, 3rd ed. World Federation of Hemophilia, 2020. https://www1.wfh.org/publications/files/pdf-1900.pdf

    Source note · professional society guidance

  9. 9. Huth-Kuhne A, et al. International recommendations on the diagnosis and treatment of patients with acquired hemophilia A. Haematologica. 2009;94:566-575. https://pmc.ncbi.nlm.nih.gov/articles/PMC2663620/

    Source note · professional society guidance

  10. 10. James PD, et al. ASH ISTH NHF WFH 2021 guidelines on the diagnosis of von Willebrand disease. Blood Advances. 2021;5:280-300. https://doi.org/10.1182/bloodadvances.2020003265

    Source note · professional society guidance

  11. 11. Levi M, et al. Disseminated intravascular coagulation and its immune mechanisms. Blood. 2022;139:1973-1980. https://doi.org/10.1182/blood.2021012524

    Source note · peer-reviewed literature

  12. 12. Clinical and Laboratory Standards Institute. H58-A, Platelet Function Testing by Aggregometry, 2008, archived but technically valid. https://clsi.org/shop/standards/h58/

    Source note · consensus standard

  13. 13. Clinical and Laboratory Standards Institute. H60-A, Laboratory Testing for the Lupus Anticoagulant, 2014, reaffirmed September 2019. https://clsi.org/shop/standards/h60/

    Source note · consensus standard

  14. 14. LatticeMLS synthesis on decision economy in coagulation test selection, derived from the sources above. Educational synthesis, not an external authority.

    Source note · module-authored