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Module HEME-01 · Version 1.0

Hematopoietic Lineages from Stem Cell to Peripheral Blood

Use a practical lineage map and visible maturation features to orient cells from marrow production to the peripheral blood film.

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Who this module is for

Foundation-level medical laboratory learners with basic cell biology preparing to review a CBC differential and peripheral smear.

Learning objectives

  • Trace erythroid, granulocytic, monocytic, megakaryocytic, and lymphoid lineages.
  • Describe predictable changes in cell size, nucleus, chromatin, nucleoli, cytoplasm, granules, and nuclear-to-cytoplasmic ratio.
  • Relate marrow production, storage, release, circulation, and tissue migration.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

15 sources

  1. 1. Bone-marrow haematopoietic-stem-cell niches. Nature Reviews Immunology.

    Source note · peer-reviewed literature

  2. 2. New paradigms on hematopoietic stem cell differentiation. Protein & Cell.

    Source note · peer-reviewed literature

  3. 3. Anaemia in kidney disease: harnessing hypoxia responses for therapy. Nature Reviews Nephrology.

    Source note · peer-reviewed literature

  4. 4. Thrombopoietin: its role from early hematopoiesis to platelet production. Haematologica.

    Source note · peer-reviewed literature

  5. 5. The White Blood Cell and Differential Count. Clinical Methods, NCBI Bookshelf.

    Source note · peer-reviewed literature

  6. 6. Primitive and definitive erythropoiesis in mammals. PMC.

    Source note · peer-reviewed literature

  7. 7. Platelets. Clinical Methods, NCBI Bookshelf.

    Source note · peer-reviewed literature

  8. 8. Understanding platelet generation from megakaryocytes. PMC.

    Source note · peer-reviewed literature

  9. 9. The Neutrophil's Role During Health and Disease. Physiological Reviews.

    Source note · peer-reviewed literature

  10. 10. Normal and Abnormal Complete Blood Count With Differential. StatPearls, NCBI Bookshelf.

    Source note · peer-reviewed literature

  11. 11. How to think about acute leukemia of ambiguous lineage. PMC.

    Source note · peer-reviewed literature

  12. 12. ICSH recommendations for nomenclature and grading of peripheral blood morphology. Int J Lab Hematol. 2015;37:287-303.

    Source note · professional society guidance

  13. 13. CLSI EP28, Defining, Establishing, and Verifying Reference Intervals.

    Source note · consensus standard

  14. 14. CLSI H20, Reference Leukocyte Differential Count and Evaluation of Instrumental Methods, 3rd ed.

    Source note · consensus standard

  15. 15. College of American Pathologists. Hematology, Coagulation, and Clinical Microscopy Checklist, HEM.34600 Criteria for Blood Film Review (Phase II). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard