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Module CC-21 · Version 1.0

Oxygen Transport and the Oxyhemoglobin Dissociation Curve

Interpret oxygen tension, saturation, hemoglobin fractions, and arterial oxygen content as related but distinct laboratory information.

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Who this module is for

Medical laboratory professionals and learners working with blood gas, co-oximetry, and oxygenation results.

Learning objectives

  • Distinguish oxygen tension, functional and fractional saturation, and oxygen content.
  • Explain right and left shifts in terms of hemoglobin affinity.
  • Recognize why calculated saturation, pulse oximetry, and co-oximetry may disagree.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

11 sources

  1. 1. Clinical and Laboratory Standards Institute. CLSI C46-A2: Blood Gas and pH Analysis and Related Measurements; Approved Guideline, 2nd ed. 2009.

    Source note · consensus standard

  2. 2. Davis MD, Walsh BK, Sittig SE, Restrepo RD. AARC Clinical Practice Guideline: Blood Gas Analysis and Hemoximetry: 2013. Respiratory Care. 2013;58(10):1694-1703.

    Source note · professional society guidance

  3. 3. US Food and Drug Administration. Pulse Oximeter Accuracy and Limitations: FDA Safety Communication. February 19, 2021.

    Source note · federal regulation

  4. 4. Brewster M, Heinzmann C, Sharma S. Oxygen Saturation. StatPearls [Internet]. Updated June 3, 2026.

    Source note · peer-reviewed literature

  5. 5. StatPearls contributors. Physiology, Oxyhemoglobin Dissociation Curve. StatPearls [Internet].

    Source note · peer-reviewed literature

  6. 6. StatPearls contributors. Physiology, Bohr Effect. StatPearls [Internet].

    Source note · peer-reviewed literature

  7. 7. Oxygen Transport: Regulation of Tissue Oxygenation. NCBI Bookshelf physiology reference text.

    Source note · peer-reviewed literature

  8. 8. Chen RJ, Nappe TM. Methemoglobinemia. StatPearls [Internet]. Updated December 14, 2025.

    Source note · peer-reviewed literature

  9. 9. StatPearls contributors. Carbon Monoxide Toxicity. StatPearls [Internet].

    Source note · peer-reviewed literature

  10. 10. StatPearls contributors. Partial Pressure of Oxygen. StatPearls [Internet].

    Source note · peer-reviewed literature

  11. 11. Preanalytical considerations in blood gas analysis. PMC full-text review.

    Source note · peer-reviewed literature