Module CC-26 · Version 1.0
Drug Metabolism and Toxicology Methods
Interpret toxicology findings by connecting specimen selection, metabolism, screening design, confirmation, and the purpose of the cutoff.
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Who this module is for
Medical laboratory science learners and laboratory staff with basic chemistry methods and pharmacokinetics.
Learning objectives
- Describe absorption, distribution, metabolism, elimination, and specimen detection windows.
- Compare immunoassay screening with chromatography-mass spectrometry confirmation.
- Distinguish a cutoff-based result from concentration, impairment, dose, or exact timing.
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
16 sources
1. 42 CFR § 493.3, Applicability, Electronic Code of Federal Regulations, current as amended.
Source note · federal regulation
2. 42 CFR § 493.1232, Standard: Specimen identification and integrity.
Source note · federal regulation
3. 42 CFR § 493.1242, Standard: Specimen submission, handling, and referral.
Source note · federal regulation
4. 42 CFR § 493.937, Toxicology proficiency testing.
Source note · federal regulation
5. SAMHSA/HHS, Mandatory Guidelines for Federal Workplace Drug Testing Programs Using Urine, effective 2024-02-01.
Source note · federal regulation
6. SAMHSA/HHS, Mandatory Guidelines for Federal Workplace Drug Testing Programs Using Oral Fluid, effective 2023-10-10.
Source note · federal regulation
7. SAMHSA, Medical Review Officer Guidance Manual for Federal Workplace Drug Testing Programs, 2025 edition.
Source note · federal guidance
8. SAMHSA, Hair External Contamination Literature Review and Drug-Free Workplace materials.
Source note · federal guidance
9. College of American Pathologists. Laboratory General Checklist, GEN.40502 Chain-of-Custody Procedures (Phase II). CAP Accreditation Program, 12.09.2025 edition.
Source note · accreditation standard
10. College of American Pathologists. Chemistry and Toxicology Checklist, CHM.15250 Toxicology Results (Phase II). CAP Accreditation Program, 12.09.2025 edition.
Source note · accreditation standard
11. CLSI C52, Toxicology and Drug Testing in the Medical Laboratory, 3rd edition.
Source note · consensus standard
12. CLSI C62, Liquid Chromatography-Mass Spectrometry Methods, 3rd edition.
Source note · consensus standard
13. ARUP Consult, Drug Testing: Choose the Right Test.
Source note · professional society guidance
14. ARUP Consult, Newborn Drug Screening: Meconium and Umbilical Cord Tissue.
Source note · professional society guidance
15. NCBI Bookshelf, Clinical Drug Testing (StatPearls).
Source note · peer-reviewed literature
16. Journal of Applied Laboratory Medicine, Opioids: Clinical Practice, Monitoring, and Medicolegal Considerations and companion pharmacogenetics review.
Source note · peer-reviewed literature