Module COAG-05 · Version 1.0
Platelet-Function Testing: Methods, Results, and Limitations
Compares light-transmission aggregometry, whole-blood impedance, high-shear closure time, lumiaggregometry, and flow cytometry as platelet-function methods, and works one PFA case through specimen validation, pattern recognition, and the boundary between a compatible pattern and a diagnosis.
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Who this module is for
Medical laboratory scientists and laboratory professionals working toward advanced coagulation testing competency, with prior grounding in basic hemostasis screening and coagulation instrumentation.
Learning objectives
- Explain the operating principle and output of major platelet-function methods
- Match agonist panels and controls to inherited, acquired, or drug-related questions
- Evaluate specimen acceptance, internal consistency, and method limitations
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
10 sources
1. Paniccia R, Priora R, Alessandrello Liotta A, Abbate R. Platelet function tests: a comparative review. Vascular Health and Risk Management. 2015;11:133-148. doi:10.2147/VHRM.S44469.
Source note · peer-reviewed literature
2. Le Blanc J, Mullier F, Vayne C, Lordkipanidze M. Advances in platelet function testing: light transmission aggregometry and beyond. Journal of Clinical Medicine. 2020;9(8):2636. doi:10.3390/jcm9082636.
Source note · peer-reviewed literature
3. Hayward CPM, et al. Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. American Journal of Clinical Pathology. 2010;134(6):955-963. doi:10.1309/AJCP9V3RRVNZMKDS.
Source note · consensus standard
4. Siemens Healthineers. Dade PFA Collagen/EPI Test Cartridge and Dade PFA Collagen/ADP Test Cartridge: Instructions for Use, 11528713_en Rev. 10, December 2022, outside USA.
Source note · manufacturer labeling
5. Clinical and Laboratory Standards Institute. H58-A: Platelet Function Testing by Aggregometry; Approved Guideline, 1st ed., 2008.
Source note · consensus standard
6. Gresele P, et al. Diagnosis of inherited platelet function disorders: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis. 2015;13(2):314-322. doi:10.1111/jth.12792.
Source note · professional society guidance
7. 42 CFR § 493.1253, Standard: Establishment and verification of performance specifications. CMS regulation.
Source note · federal regulation
8. 42 CFR § 493.1256, Standard: Control procedures. CMS regulation.
Source note · federal regulation
9. College of American Pathologists. Laboratory Accreditation Program.
Source note · accreditation standard
10. Centers for Medicare & Medicaid Services. Clinical Laboratory Improvement Amendments (CLIA). Federal program overview, updated 2026-05-14.
Source note · federal guidance