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Module HEME-03 · Version 1.0

Normal Red Cells and Platelets

Establish a defensible visual baseline for normal red-cell and platelet backgrounds before naming abnormalities.

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Who this module is for

Foundation-level medical laboratory personnel with microscope and smear-preparation basics.

Learning objectives

  • Use a normal small lymphocyte nucleus as an approximate size reference.
  • Describe normal RBC shape, central pallor, and distribution in the monolayer.
  • Estimate platelet adequacy and recognize normal size variation without overcalling artifacts.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

12 sources

  1. 1. CLSI. Reference Leukocyte Differential Count (Proportional) and Evaluation of Instrumental Methods. 3rd ed. CLSI standard H20. Clinical and Laboratory Standards Institute; 2026.

    Source note · consensus standard

  2. 2. Palmer L, Briggs C, De La Salle B, et al. ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. Int J Lab Hematol. 2015;37:287-303.

    Source note · consensus standard

  3. 3. Croatian Chamber of Medical Biochemists Working Group for Laboratory Hematology. National recommendations: management of samples with suspected EDTA-induced pseudothrombocytopenia. PMC.

    Source note · peer-reviewed literature

  4. 4. Platelet satellitism (review). PMC.

    Source note · peer-reviewed literature

  5. 5. American Society of Hematology Image Bank. Giant platelets, atlas entry.

    Source note · professional society guidance

  6. 6. Platelet count assessment from peripheral blood smear: correlation with automated count. PubMed.

    Source note · peer-reviewed literature

  7. 7. Mean platelet volume: the need for a reference method. Am J Clin Pathol. 1984;81(6):769, with routine method comparison literature.

    Source note · peer-reviewed literature

  8. 8. Peripheral Blood Smear. In: Clinical Methods, 3rd ed. NCBI Bookshelf.

    Source note · peer-reviewed literature

  9. 9. Peripheral blood film: a review. PMC.

    Source note · peer-reviewed literature

  10. 10. CLSI PRE04 Preexamination processes and Wright stain manufacturer protocol.

    Source note · consensus standard

  11. 11. Wright-Giemsa Stain package insert / procedure. Merck/Sigma-Aldrich.

    Source note · manufacturer labeling

  12. 12. Representative clinical laboratory platelet-count directory cross-checked with ICSH size terminology.

    Source note · peer-reviewed literature