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Module HEME-08 · Version 1.0

Red-Cell Size, Color, and Distribution

Use the monolayer, CBC indices, histogram shape, and specimen context to describe red-cell size, hemoglobinization, and population distribution without assigning an unsupported cause.

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Who this module is for

Foundation-level medical laboratory professionals who review CBC results and peripheral blood smears.

Learning objectives

  • Use a stated size reference and the monolayer description to assess red-cell size and central pallor.
  • Differentiate a uniform size shift from increased size variation and a dimorphic population.
  • Correlate morphology with MCV, MCHC, RDW, reticulocyte response, and histogram shape while choosing a bounded laboratory action.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

12 sources

  1. 1. Palmer L, Briggs C, McFadden S, et al. ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. International Journal of Laboratory Hematology. 2015;37(3):287-303. doi:10.1111/ijlh.12327.

    Source note · consensus standard

  2. 2. Clinical and Laboratory Standards Institute. H20: Reference Leukocyte Differential Count (Proportional) and Evaluation of Instrumental Methods. 3rd ed. Wayne, PA: CLSI; 2026.

    Source note · consensus standard

  3. 3. College of American Pathologists. Hematology and Coagulation Checklist, sample. Northfield, IL: CAP; 2020.

    Source note · accreditation standard

  4. 4. Centers for Medicare & Medicaid Services. 42 CFR 493.1291, Standard: Test report.

    Source note · federal regulation

  5. 5. Centers for Medicare & Medicaid Services. 42 CFR 493.1251 and 493.1291, procedure manual and test report standards.

    Source note · federal regulation

  6. 6. Lynch EC. Peripheral Blood Smear. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990.

    Source note · peer-reviewed literature

  7. 7. Sarma PR. Red Cell Indices. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990.

    Source note · peer-reviewed literature

  8. 8. Bessman JD. Reticulocytes. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990.

    Source note · peer-reviewed literature

  9. 9. Bain BJ. Peripheral blood film, a review. Annals of Ibadan Postgraduate Medicine. 2014;12(2):71-79.

    Source note · peer-reviewed literature

  10. 10. Berda-Haddad Y, et al. Cold agglutinin disease: a laboratory challenge. Biochemia Medica. 2015;25(3):310-314.

    Source note · peer-reviewed literature

  11. 11. Zandecki M, Genevieve F, Gerard J, Godon A. Spurious counts and spurious results on haematology analysers: a review. Part II. International Journal of Laboratory Hematology. 2007;29(1):21-41.

    Source note · peer-reviewed literature

  12. 12. UChicago Medicine Medical Laboratories. Complete Blood Count. Adult and pediatric test catalog reference values.

    Source note · laboratory reference