LatticeMLS
Menu

Module HEME-10 · Version 1.0

Aggregation and Distortion: Rouleaux, Agglutination, and Artifacts

Use smear distribution and CBC plausibility to distinguish rouleaux, cold-reactive agglutination, and preparation artifacts, then choose only validated corrective actions.

Your next section

Start section 1

Read without an account. Sign in to save.

Who this module is for

Medical laboratory professionals performing CBC review and peripheral smear assessment.

Learning objectives

  • Distinguish rouleaux from agglutination using stack or clump arrangement and neighboring-cell findings.
  • Calculate and assess MCH and MCHC with exact units while recognizing in vitro agglutination interference.
  • Choose conditional warming, saline evaluation, rerun, or recollection actions and release only corrected results that meet local criteria.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

12 sources

  1. 1. 42 CFR § 493.1251, Standard: Procedure manual. Federal regulation, United States.

    Source note · federal regulation

  2. 2. 42 CFR § 493.1256, Standard: Control procedures. Federal regulation, United States.

    Source note · federal regulation

  3. 3. College of American Pathologists, Hematology and Coagulation Checklist, blood-film review requirements.

    Source note · accreditation standard

  4. 4. Clinical and Laboratory Standards Institute, H20: Reference Leukocyte Differential Count and Evaluation of Instrumental Methods.

    Source note · consensus standard

  5. 5. Clinical and Laboratory Standards Institute, H26: Validation, Verification, and Quality Assurance of Automated Hematology Analyzers.

    Source note · consensus standard

  6. 6. Palmer L, Briggs C, McFadden S, et al. ICSH recommendations for standardization of peripheral blood morphology. International Journal of Laboratory Hematology. 2015;37:287-303.

    Source note · consensus standard

  7. 7. Gulati G, Uppal G, Gong J. Unreliable automated complete blood count results: causes, recognition, and resolution. Annals of Laboratory Medicine. 2022;42:515-530.

    Source note · peer-reviewed literature

  8. 8. Zandecki M, Genevieve F, Gerard J, Godon A. Spurious counts and spurious results on haematology analysers. International Journal of Laboratory Hematology. 2007;29:21-41.

    Source note · peer-reviewed literature

  9. 9. Berentsen S. How I manage patients with cold agglutinin disease. British Journal of Haematology. 2018;181:320-330.

    Source note · peer-reviewed literature

  10. 10. Johnson ST, Jajosky RP. Evaluating patients with autoimmune hemolytic anemia. Hematology ASH Education Program. 2022;2022:96-104.

    Source note · professional society guidance

  11. 11. Baskurt OK, Neu B, Meiselman HJ. Red blood cell aggregation. CRC Press; 2011.

    Source note · peer-reviewed literature

  12. 12. Lynch EC. Peripheral Blood Smear. Clinical Methods. 3rd ed. 1990.

    Source note · professional society guidance