Module HEME-26 · Version 1.0
Myelodysplastic Neoplasms: Building an Integrated Workup
Recognize concerning cytopenia and dysplasia patterns, exclude common mimics, and select the marrow and ancillary evidence needed for integrated MDS classification.
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Who this module is for
Medical laboratory scientists and hematology laboratory professionals who review CBC flags, peripheral smears, and marrow ancillary data.
Learning objectives
- Identify representative erythroid, granulocytic, and megakaryocytic dysplasia.
- Distinguish persistent, significant dysplasia from artifact or reactive change.
- Explain how blast assessment, cytogenetics, molecular testing, and exclusion of mimics support integrated classification.
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
11 sources
1. Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36:1703-1719. doi:10.1038/s41375-022-01613-1.
Source note · peer-reviewed literature
2. Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias: integrating morphologic, clinical, and genomic data. Blood. 2022;140:1200-1228. doi:10.1182/blood.2022015850.
Source note · peer-reviewed literature
3. Lee SH, Erber WN, Porwit A, Tomonaga M, Peterson LC. ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol. 2008;30:349-364. doi:10.1111/j.1751-553X.2008.01100.x.
Source note · consensus standard
4. International Council for Standardization in Haematology. Recommendations for standardization of nomenclature and grading of peripheral blood cell morphological features.
Source note · consensus standard
5. International Consortium for MDS. Contemporary Approach to the Diagnosis and Classification of Myelodysplastic Neoplasms/Syndromes: Recommendations from the International Consortium for MDS. Blood Cancer Journal. 2024.
Source note · professional society guidance
6. Centers for Medicare & Medicaid Services. 42 CFR §493.1253, Establishment and verification of performance specifications.
Source note · federal regulation
7. Centers for Medicare & Medicaid Services. 42 CFR §493.1256, Control procedures.
Source note · federal regulation
8. Centers for Medicare & Medicaid Services. 42 CFR §493.1291, Standard: Test report.
Source note · federal regulation
9. Clinical and Laboratory Standards Institute. H20, Reference Leukocyte Differential Count (Proportional) and Evaluation of Instrumental Methods.
Source note · consensus standard
10. Clinical and Laboratory Standards Institute. EP15, User Verification of Precision and Estimation of Bias.
Source note · consensus standard
11. Clinical and Laboratory Standards Institute. EP28, Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory.
Source note · consensus standard