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Module COAG-07 · Version 1.0

Acquired Coagulopathy, Consumption, and Thrombotic Patterns

A working framework for reading deteriorating platelet count, PT, aPTT, fibrinogen, and D-dimer together over time, separating an evolving consumption pattern from liver-related, dilutional, vitamin K-related, and thrombotic microangiopathy look-alikes, and deciding what needs urgent communication.

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Who this module is for

Clinical laboratory scientists and trainees who already read a single PT/aPTT/platelet/fibrinogen panel and now need to interpret two or more panels drawn over time in an acutely ill patient.

Learning objectives

  • Distinguish a consumption pattern from liver-related factor reduction, vitamin K-related change, dilution, and a thrombotic microangiopathy pattern using platelet count, PT/aPTT, fibrinogen, and D-dimer.
  • Use serial trends in these results rather than one snapshot to judge whether a pattern is developing.
  • Identify which trend or result requires urgent review or communication under local policy.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

12 sources

  1. 1. Iba T, Levy JH, Maier CL, et al. Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation. Journal of Thrombosis and Haemostasis. 2025;23(7):2356-2362. doi:10.1016/j.jtha.2025.03.038.

    Source note · peer-reviewed literature

  2. 2. Clinical and Laboratory Standards Institute. H47, 3rd ed: One-Stage Prothrombin Time (PT) Test and Activated Partial Thromboplastin Time (APTT) Test. Wayne, PA: CLSI; 2023.

    Source note · consensus standard

  3. 3. Clinical and Laboratory Standards Institute. H21, 6th ed: Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays. Wayne, PA: CLSI; 2024.

    Source note · consensus standard

  4. 4. Electronic Code of Federal Regulations. 42 CFR 493.1256, Standard: Control procedures.

    Source note · federal regulation

  5. 5. Electronic Code of Federal Regulations. 42 CFR 493.1269, Standard: Hematology.

    Source note · federal regulation

  6. 6. College of American Pathologists. Hematology and Coagulation Checklist, public sample edition, 2022.

    Source note · accreditation standard

  7. 7. Nehring SM, Goyal A, Bansal P, Patel BC. Disseminated Intravascular Coagulation. StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing; updated 2024 May 1.

    Source note · peer-reviewed literature

  8. 8. Killeen RB, Kok SJ. D-Dimer Test. StatPearls [Internet]. Treasure Island, FL: StatPearls Publishing.

    Source note · peer-reviewed literature

  9. 9. Nguyen G, Lejeune M, Crichi B, Frere C. Hemostasis testing in patients with liver dysfunction: Advantages and caveats. World Journal of Gastroenterology. 2021;27(42):7285-7298. doi:10.3748/wjg.v27.i42.7285.

    Source note · peer-reviewed literature

  10. 10. Hardy JF, de Moerloose P, Samama CM. Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Canadian Journal of Anesthesia. 2006;53(Suppl 2):S40-S58.

    Source note · peer-reviewed literature

  11. 11. Joly BS, Coppo P, Veyradier A. Clinical and laboratory diagnosis of thrombotic thrombocytopenic purpura: an integrated approach. Hematology American Society of Hematology Education Program. 2018;2018(1):530-537.

    Source note · professional society guidance

  12. 12. Merck Manual Professional Edition. Vitamin K Deficiency. Revised June 2026.

    Source note · professional society guidance