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Module COAG-10 · Version 1.0

Lupus Anticoagulant Evaluation as a Laboratory Workflow

Work through the screen, mix, and confirm logic that a coagulation laboratory uses to evaluate lupus anticoagulant across two complementary assay principles, dRVVT and a silica-based aPTT system, and choose a defensible report category with the correct limitation language.

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Who this module is for

Medical laboratory scientists and students working toward independent bench release of coagulation special testing, familiar with routine PT/aPTT and basic mixing studies.

Learning objectives

  • Explain screen, mix, confirm, normalized ratios, and phospholipid dependence in lupus anticoagulant testing
  • Use dRVVT and a sensitive silica-based aPTT system as complementary methods rather than interchangeable tests
  • Recognize anticoagulant interference, factor deficiency, acute-phase effects, and testing-timing limitations that affect interpretability

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

10 sources

  1. 1. Devreese KMJ, de Groot PG, de Laat B, et al. Update of the guidelines for lupus anticoagulant detection and interpretation. ISTH SSC guidance. Journal of Thrombosis and Haemostasis. 2020;18:2828-2839.

    Source note · professional society guidance

  2. 2. Tripodi A, Cohen H, Devreese KMJ. Lupus anticoagulant detection in anticoagulated patients. Guidance from the ISTH SSC. Journal of Thrombosis and Haemostasis. 2020;18:1569-1575.

    Source note · professional society guidance

  3. 3. Favaloro EJ, Pasalic L. Lupus anticoagulant testing during anticoagulation, including direct oral anticoagulants. Research and Practice in Thrombosis and Haemostasis. 2022;6:e12676.

    Source note · peer-reviewed literature

  4. 4. Clinical and Laboratory Standards Institute. H60: Laboratory Testing for the Lupus Anticoagulant, 1st ed., reaffirmed September 2019. CLSI; 2014.

    Source note · consensus standard

  5. 5. Baker SA, Jin J, Pfaffroth C, Vu T, Zehnder JL. DOAC-Stop in lupus anticoagulant testing: Direct oral anticoagulant interference removed in most samples. Research and Practice in Thrombosis and Haemostasis. 2021;5:e12472.

    Source note · peer-reviewed literature

  6. 6. Schouwers SME, Delanghe JR, Devreese KMJ. Laboratory diagnosis of antiphospholipid syndrome: Insights and hindrances. Journal of Clinical Medicine. 2022;11:2164.

    Source note · peer-reviewed literature

  7. 7. College of American Pathologists. Hematology and Coagulation Checklist, HEM.37175, platelet-poor plasma. 2020.

    Source note · accreditation standard

  8. 8. 42 CFR §§493.1251, 493.1253, and 493.1256, Condition: Laboratories performing high complexity testing, procedure manual, performance specifications, and control procedures.

    Source note · federal guidance

  9. 9. 42 CFR §493.1253, establishment of performance specifications for modified or unestablished test systems.

    Source note · federal guidance

  10. 10. Barbhaiya M, et al. The 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria. Arthritis & Rheumatology. 2023;75:1687-1702.

    Source note · professional society guidance