Module HEME-11 · Version 1.0
Red-Cell Inclusions and What They Represent
Use morphology, stain selection, and bounded interpretation to distinguish common red-cell inclusions from look-alikes.
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Who this module is for
Medical laboratory scientists and trainees performing or reviewing peripheral smear morphology.
Learning objectives
- Compare selected RBC inclusions and look-alikes by location, shape, number, distribution, neighboring cells, and stain behavior.
- Use Perls and supravital stains only with valid controls and report their bounded material support.
- Route artifact, parasite-like material, supported inclusion, and unresolved findings to the appropriate release or escalation endpoint.
How completion works
Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.
Sources
13 sources
1. College of American Pathologists. Hematology and Clinical Microscopy Glossary, 2025, Erythrocyte Inclusions entries.
Source note · professional society guidance
2. Palmer L, Briggs C, McFadden S, et al. ICSH recommendations for standardization of nomenclature and grading of peripheral blood cell morphology. International Journal of Laboratory Hematology. 2015;37:287-303.
Source note · consensus standard
3. Centers for Medicare & Medicaid Services. 42 CFR §493.1251, Standard: Procedure manual.
Source note · federal regulation
4. Centers for Medicare & Medicaid Services. 42 CFR §493.1256, Standard: Control procedures.
Source note · federal regulation
5. Suttle A, et al. Erythrocyte Inclusions. StatPearls, NCBI Bookshelf, updated 2024.
Source note · peer-reviewed literature
6. Adebayo P, et al. Histology, Basophilic Stippling. StatPearls, NCBI Bookshelf, updated 2024.
Source note · peer-reviewed literature
7. Naik R, et al. Histology, Howell Jolly Bodies. StatPearls, NCBI Bookshelf, updated 2023.
Source note · peer-reviewed literature
8. American Society of Hematology. Cabot ring. ASH Image Bank.
Source note · professional society guidance
9. Merck Manual Professional Edition. Glucose-6-Phosphate Dehydrogenase Deficiency.
Source note · professional society guidance
10. American Society of Hematology. Hemoglobin C Crystals. ASH Image Bank.
Source note · professional society guidance
11. American Society of Hematology. Hemoglobin Electrophoresis in Sickle Cell Disease: A Primer for the Clinician, 2021.
Source note · professional society guidance
12. Centers for Disease Control and Prevention. Appendix: Microscopic Procedures for Diagnosing Malaria.
Source note · federal guidance
13. Centers for Disease Control and Prevention. Malaria Diagnostic Tests.
Source note · federal guidance