LatticeMLS
Menu

Module HEME-14 · Version 1.0

Macrocytic Anemia Patterns

Organize macrocytosis with the CBC, peripheral smear, reticulocytes, nutrient markers, chemistry, and escalation findings without turning a pattern into a diagnosis.

Your next section

Start section 1

Read without an account. Sign in to save.

Who this module is for

Medical laboratory scientists and trainees interpreting CBC and peripheral smear findings in an applied hematology workflow.

Learning objectives

  • Differentiate macro-ovalocytic and megaloblastic morphology from round macrocytosis.
  • Interpret vitamin B12, folate, methylmalonic acid, homocysteine, reticulocytes, liver and thyroid tests, and medication context as pattern evidence.
  • Recognize pancytopenia, dysplasia, or blasts as findings requiring qualified morphology review and escalation.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

11 sources

  1. 1. Aslinia F, Mazza JJ, Yale SH. Megaloblastic Anemia and Other Causes of Macrocytosis. Clinical Medicine & Research. 2006;4(3):236-241.

    Source note · peer-reviewed literature

  2. 2. Killeen RB, Adil A. Macrocytic Anemia. StatPearls. Updated 2025-04-04.

    Source note · peer-reviewed literature

  3. 3. National Institutes of Health Office of Dietary Supplements. Vitamin B12: Fact Sheet for Health Professionals.

    Source note · professional society guidance

  4. 4. National Institutes of Health Office of Dietary Supplements. Folate: Fact Sheet for Health Professionals.

    Source note · professional society guidance

  5. 5. World Health Organization. Guideline on haemoglobin cutoffs to define anaemia in individuals and populations. 2024.

    Source note · professional society guidance

  6. 6. 42 CFR 493.1251. Standard: Procedure manual.

    Source note · federal regulation

  7. 7. 42 CFR 493.1253. Standard: Establishment and verification of performance specifications.

    Source note · federal regulation

  8. 8. 42 CFR 493.1252. Standard: Test systems, equipment, instruments, reagents, materials, and supplies.

    Source note · federal regulation

  9. 9. College of American Pathologists. All Common Checklist. Current edition.

    Source note · accreditation standard

  10. 10. Clinical and Laboratory Standards Institute. EP28: Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory.

    Source note · consensus standard

  11. 11. International Council for Standardization in Haematology. Publications and morphology recommendations.

    Source note · consensus standard