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Module HEME-18 · Version 1.0

Hemoglobin S Disorders and Common Analytical Patterns

Interpret HbS-containing patterns with fraction accounting, paired methods, morphology, age, and transfusion history while keeping genotype confirmation bounded.

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Who this module is for

Medical laboratory scientists and trainees who review hemoglobin separation results, newborn-screening patterns, and supporting hematology data.

Learning objectives

  • Identify HbS on at least two complementary method types.
  • Use HbA, HbA2, HbF, CBC, reticulocytes, age, and transfusion history to organize common patterns.
  • Recognize co-migration and sickling-solubility test limitations and select an orthogonal confirmation.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

10 sources

  1. 1. Centers for Medicare & Medicaid Services. 42 CFR §§493.1252-493.1255: Test systems; establishment and verification of performance specifications; maintenance and function checks; calibration and calibration verification procedures. 2025 Title 42 CFR compilation.

    Source note · federal regulation

  2. 2. College of American Pathologists. Accreditation Checklists. Current laboratory-specific checklist access page.

    Source note · accreditation standard

  3. 3. Clinical and Laboratory Standards Institute. NBS01: Dried Blood Spot Specimen Collection for Newborn Screening, 7th ed., 2021.

    Source note · consensus standard

  4. 4. Centers for Disease Control and Prevention and Association of Public Health Laboratories. Hemoglobinopathies: Current Practices for Screening, Confirmation and Follow-up. 2015.

    Source note · federal guidance

  5. 5. Streck. SICKLEDEX Instructions for Use, document 350430-27, revision 2024-05.

    Source note · manufacturer labeling

  6. 6. Bender MA, Carlberg K. Sickle Cell Disease. GeneReviews, updated 2024.

    Source note · peer-reviewed literature

  7. 7. Sridhar A, Idowu M. Hemoglobin Electrophoresis in Sickle Cell Disease: A Primer for the Clinician. American Society of Hematology, 2021.

    Source note · professional society guidance

  8. 8. Bain BJ. The spectrum of sickle cell disease. American Journal of Hematology. 2025;100:296-297. doi:10.1002/ajh.27494.

    Source note · peer-reviewed literature

  9. 9. World Health Organization. Sickle-cell disease. Fact sheet, 2025.

    Source note · international health guidance

  10. 10. Centers for Disease Control and Prevention. About Newborn Screening Laboratories, updated 2026.

    Source note · federal guidance