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Module HEME-19 · Version 1.0

Iron Studies and Hereditary Hemochromatosis

Interpret serum iron, transferrin saturation, ferritin, inflammatory context, liver injury, and targeted HFE testing without treating a single result as proof of iron overload.

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Who this module is for

Medical laboratory scientists and laboratory professionals who release iron studies or support genetic test reporting.

Learning objectives

  • Calculate and interpret transferrin saturation with attention to timing and variability.
  • Differentiate storage elevation from increased circulating iron availability.
  • Explain the limited penetrance and scope of common HFE variant testing.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

11 sources

  1. 1. European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. Journal of Hepatology. 2022;77(2):479-502. doi:10.1016/j.jhep.2022.03.033. (Biochemical-suspicion thresholds and MRI/biopsy confirmation rule.)

    Source note · professional society guidance

  2. 2. Barton JC, Parker CJ. HFE-Related Hemochromatosis. GeneReviews®, University of Washington, Seattle. Updated 2024-04-11.

    Source note · peer-reviewed literature

  3. 3. Anderson GJ, Frazer DM. Current understanding of iron homeostasis. American Journal of Clinical Nutrition. 2017;106(Suppl 6):1559S-1566S. doi:10.3945/ajcn.117.155804.

    Source note · peer-reviewed literature

  4. 4. Mayo Clinic Laboratories. SFEC: Iron and Total Iron-Binding Capacity, Serum. Test catalog entry (collection guidance and teaching intervals).

    Source note · laboratory reference

  5. 5. Mayo Clinic Laboratories. FERR1: Ferritin, Serum.

    Source note · laboratory reference

  6. 6. Centers for Medicare & Medicaid Services. 42 CFR §493.1253, Standard: Establishment and verification of performance specifications.

    Source note · federal regulation

  7. 7. Centers for Medicare & Medicaid Services. 42 CFR §493.1256, Standard: Control procedures.

    Source note · federal regulation

  8. 8. College of American Pathologists. All Common Checklist, COM.40475 Method Validation and Verification Approval - Nonwaived Tests (Phase II). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard

  9. 9. College of American Pathologists. All Common Checklist, COM.40605 Reference Intervals (Phase II). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard

  10. 10. Clinical and Laboratory Standards Institute. EP28-A3c: Defining, Establishing, and Verifying Clinical Laboratory Reference Intervals. Third Edition.

    Source note · consensus standard

  11. 11. Roche Diagnostics. Elecsys Ferritin, Method Sheet 07027273501, Version 4.0. June 2024.

    Source note · manufacturer labeling