What the film supports and what it does not

The film supports a high-concern myeloid morphology clue with immature cells, Auer rod-like inclusions, and dysgranulopoietic features. It does not support a leukemia subtype from morphology alone. WHO-HAEM5 classification integrates morphology with immunophenotypic, cytogenetic, and molecular data, and classification frameworks differ from ICC 2022.

An Auer rod is not synonymous with acute myeloid leukemia. WHO-HAEM5 includes Auer rods among criteria for myelodysplastic neoplasm with increased blasts-2, which reinforces the need for integrated classification. A suggestive MYH9 pattern also needs the appropriate diagnostic pathway rather than a smear-only diagnosis.

Use the local validated method, analyzer settings, stain details, review triggers, image retention rule, report wording, and notification procedure. Release objective morphology and documented escalation; leave final disease and organism identification to the appropriate integrated pathway.