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Module HEME-25 · Version 1.0

Chronic Myeloid Leukemia: Pattern, Confirmation, and Molecular Monitoring

Recognize a CML-supportive blood pattern, select bounded BCR::ABL1 confirmation, and protect molecular trend interpretation from method-related error.

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Who this module is for

Medical laboratory scientists and hematology staff who review CBC flags, peripheral smears, and molecular reports.

Learning objectives

  • Identify neutrophilic leukocytosis with a full maturation spectrum, basophilia, eosinophilia, and related CBC findings.
  • Differentiate a CML-supportive pattern from common reactive leukemoid patterns.
  • Explain BCR::ABL1 detection, transcript reporting, and standardized molecular monitoring concepts.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

10 sources

  1. 1. Cross NC, Ernst T, Branford S, et al. European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia. Leukemia. 2023;37:2150-2167. doi:10.1038/s41375-023-02048-y.

    Source note · professional society guidance

  2. 2. Apperley JF, Milojkovic D, Cross NCP, et al. 2025 European LeukemiaNet recommendations for the management of chronic myeloid leukemia. Leukemia. 2025;39:1797-1813. doi:10.1038/s41375-025-02664-w.

    Source note · professional society guidance

  3. 3. Khoury JD, Solary E, Abla O, et al. The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms. Leukemia. 2022;36:1703-1719. doi:10.1038/s41375-022-01613-1.

    Source note · professional society guidance

  4. 4. Gianelli U, Thiele J, Orazi A, et al. International Consensus Classification of myeloid and lymphoid neoplasms: myeloproliferative neoplasms. Virchows Archiv. 2023;482:53-68. doi:10.1007/s00428-022-03480-8.

    Source note · consensus standard

  5. 5. Thompson PA, Kantarjian HM, Cortes JE. Diagnosis and treatment of chronic myeloid leukemia in 2015. Mayo Clinic Proceedings. 2015;90:1440-1454. doi:10.1016/j.mayocp.2015.08.010.

    Source note · peer-reviewed literature

  6. 6. Abukhiran I, Jasser J, Syrbu S. Paraneoplastic leukemoid reactions induced by cytokine-secreting tumours. Journal of Clinical Pathology. 2020;73:310-313. doi:10.1136/jclinpath-2019-206340.

    Source note · peer-reviewed literature

  7. 7. Centers for Medicare & Medicaid Services. 42 CFR §493.1253, Standard: Establishment and verification of performance specifications.

    Source note · federal regulation

  8. 8. Clinical and Laboratory Standards Institute. Verifying Performance Claims for Medical Laboratory Tests, September 1, 2025.

    Source note · consensus standard

  9. 9. Clinical and Laboratory Standards Institute. EP15, User Verification of Precision and Estimation of Bias.

    Source note · consensus standard

  10. 10. Clinical and Laboratory Standards Institute. EP17, Evaluation of Detection Capability for Clinical Laboratory Measurement Procedures.

    Source note · consensus standard