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Module HEME-31 · Version 1.0

Pediatric Leukemia and Hemoglobinopathy Cases

Interpret pediatric leukemia and hemoglobinopathy cases by integrating age-specific CBC and smear evidence, flow context, newborn hemoglobin patterns, transfusion history, specimen stewardship, and urgent communication boundaries.

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Who this module is for

Advanced medical laboratory scientists and hematology laboratory staff who interpret pediatric CBC, morphology, flow, and hemoglobin testing.

Learning objectives

  • Recognize pediatric acute-leukemia concern even with subtle or low-count presentations.
  • Interpret newborn and child hemoglobin patterns with age and transfusion context.
  • Protect specimens and communicate urgent findings using pediatric-specific pathways.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

14 sources

  1. 1. Adeli K, et al. CALIPER Hematology Reference Standards (I): Improving Laboratory Test Interpretation in Children, Beckman Coulter DxH 900. Am J Clin Pathol. 2020;154:330-341.

    Source note · peer-reviewed literature

  2. 2. National Cancer Institute. Childhood Acute Lymphoblastic Leukemia Treatment (PDQ), Health Professional Version, issued 2026-02-10.

    Source note · federal guidance

  3. 3. Clinical and Laboratory Standards Institute. H43-A2, Clinical Flow Cytometric Analysis of Neoplastic Hematolymphoid Cells, Approved Guideline, 2nd ed., 2007, reaffirmed 2017.

    Source note · consensus standard

  4. 4. World Health Organization Classification of Tumours Editorial Board. Haematolymphoid Tumours, 5th ed., Volume 11, IARC, 2024.

    Source note · professional society guidance

  5. 5. Arber DA, Orazi A, Hasserjian RP, et al. International Consensus Classification of Myeloid Neoplasms and Acute Leukemias. Blood. 2022;140:1200-1228.

    Source note · peer-reviewed literature

  6. 6. Cairo MS, Bishop M. Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol. 2004;127:3-11.

    Source note · peer-reviewed literature

  7. 7. 42 CFR §493.1291, Standard: Test report, current eCFR.

    Source note · federal regulation

  8. 8. 42 CFR §493.1232, Standard: Specimen identification and integrity, current eCFR.

    Source note · federal regulation

  9. 9. College of American Pathologists. All Common Checklist, COM.06000 Specimen Collection Manual (Phase II). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard

  10. 10. College of American Pathologists. All Common Checklist, COM.06100 Primary Specimen Container Labeling (Phase II). CAP Accreditation Program, 12.09.2025 edition.

    Source note · accreditation standard

  11. 11. Association of Public Health Laboratories and Centers for Disease Control and Prevention. Hemoglobinopathies: Current Practices for Screening, Confirmation and Follow-up. December 2015.

    Source note · federal guidance

  12. 12. World Health Organization. Sickle-cell disease fact sheet, updated 2025-08-06.

    Source note · professional society guidance

  13. 13. Howie SRC. Safe blood sample volume limits in children. Bull World Health Organ. 2011;89:46-53.

    Source note · peer-reviewed literature

  14. 14. Local laboratory approved critical-result, specimen acceptance, flow triage, newborn-screen follow-up, and pediatric phlebotomy procedures. Local document-control system.

    Source note · laboratory reference