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Work the case from chemistry to sediment

The first-morning clean-catch specimen was collected at 08:10, received at 08:40, and tested within the analyzer stability window. Creatinine was enzymatic and IDMS-traceable at 1.4 mg/dL against a local 0.6-1.3 mg/dL interval. eGFRcr 52 mL/min/1.73 m^2 is G3a.

ACR 145 mg/g is A2. PCR is reported as 210 mg/g; this package supplies no source-backed PCR decision threshold, so interpretation depends on the laboratory's local PCR interval. Protein 1+ is a product-specific dipstick grade, not a concentration-normalized ACR/PCR result. Repeat first-morning ACR is needed before treating albuminuria as established.

Under the illustrative local microscopy rule, blood 2+ with 3–5 RBC/hpf supports intact-RBC hematuria. A 2+ blood pad with only 0–2 RBC/hpf would be discordant and would raise hemoglobin, myoglobin, lysed cells, or interference. Granular casts provide renal-parenchymal context; muddy-brown granular casts are the specific morphology clue for tubular injury, not a synonym for every granular cast. Absence of RBC casts on one preparation does not rule out glomerular bleeding. Record corroborating and limiting evidence separately.

Illustrative drawing — this picture was drawn rather than captured.

Two scales plot case eGFR 52 in G3a and ACR 145 in A2 against category boundaries.
Figure 1Case eGFR and ACR against KDIGO category boundaries.

Illustrative drawing — this picture was drawn rather than captured.

Sediment thumbnails show RBC, WBC, granular, and hyaline casts. Muddy-brown granular casts are a specific tubular-injury morphology clue; not every granular cast is muddy brown.
Figure 2Sediment morphology thumbnails: muddy-brown granular casts are a specific tubular-injury morphology clue; not every granular cast is muddy brown.
Guided case results
StudyResultMethodAnchor
Creatinine1.4 mg/dLEnzymatic, IDMS-traceableInterval 0.6-1.3 mg/dL
eGFRcr52 mL/min/1.73 m^22021 CKD-EPIG3a
ACR145 mg/gFirst-morning spotA2
PCR210 mg/gReflex ratioInterpret using local PCR interval
SedimentRBC 3-5/hpf; granular casts 1-2/lpfCentrifuged preparationIllustrative local rule: supports intact-RBC hematuria

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Which bounded statement fits this case: blood 2+ with 3–5 RBC/hpf under the stated local microscopy rule?

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