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Module HEME-02 · Version 1.0

Bone Marrow Collection and Basic Morphologic Review

Evaluate marrow aspirate and core-related specimen quality, allocate material deliberately, and complete an introductory, preparation-aware morphologic review without issuing a diagnosis.

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Who this module is for

Medical laboratory scientists and technicians who have completed HEME-01 and normal blood morphology.

Learning objectives

  • Distinguish aspirate, touch preparation, clot section, and core biopsy contributions.
  • Recognize adequacy, spicules, hemodilution, crush artifact, clotting, and staining problems.
  • Describe cellularity, lineage maturation, M:E relationship, megakaryocytes, iron assessment, and abnormal-cell escalation at an introductory level.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

14 sources

  1. 1. Lee SH, Erber WN, Porwit A, Tomonaga M, Peterson LC; International Council for Standardization in Haematology. ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol. 2008;30(5):349-364.

    Source note · consensus standard

  2. 2. International Council for Standardization in Haematology. ICSH Guidelines for the Standardization of Bone Marrow Specimens and Reports, full text PDF, Lee et al., 2008.

    Source note · consensus standard

  3. 3. College of American Pathologists. Initial Diagnostic Workup of Acute Leukemia guidance, Arber DA et al. Arch Pathol Lab Med. 2017;141(10):1342-1393.

    Source note · accreditation standard

  4. 4. Rathi V, et al. Laboratory Evaluation of Bone Marrow. StatPearls [Internet]. Updated 2023.

    Source note · peer-reviewed literature

  5. 5. Determination of age-dependent bone marrow normocellularity. Am J Clin Pathol. 2024;161(2):170-179.

    Source note · peer-reviewed literature

  6. 6. Patholines.org. Bone Marrow hematopathology reference summary.

    Source note · professional society guidance

  7. 7. Mufti GJ, Bennett JM, Goasguen J, et al. Diagnosis and classification of myelodysplastic syndrome: IWGM-MDS consensus proposals. Haematologica. 2008;93(11):1712-1717.

    Source note · consensus standard

  8. 8. Groupe Francophone d'Hematologie Cellulaire. Perls' Stain Guidelines from the French-Speaking Cellular Hematology Group.

    Source note · professional society guidance

  9. 9. Khoury JD, Solary E, Abla O, et al. WHO 5th edition classification of myeloid and histiocytic/dendritic neoplasms. Leukemia. 2022;36(7):1703-1719.

    Source note · peer-reviewed literature

  10. 10. 42 CFR 493.1242. Standard: Specimen submission, handling, and referral. CMS CLIA regulation.

    Source note · federal regulation

  11. 11. 42 CFR 493.1291. Standard: Test report. CMS CLIA regulation.

    Source note · federal regulation

  12. 12. Quest Diagnostics. Hematopathology specimen handling and requirements, test directory.

    Source note · manufacturer labeling

  13. 13. American College of Medical Genetics and Genomics. Technical laboratory standards for cytogenomic studies of acquired chromosomal abnormalities. Genet Med. 2023.

    Source note · professional society guidance

  14. 14. American Society of Hematology. Demystifying the Bone Marrow Biopsy: A Hematopathology Primer. 2021.

    Source note · professional society guidance