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Section 6 of 6 · Open sections

Required section · Section 6 of 6

Debrief: correlate, qualify, and escalate

The evidence supports a particulate, adequately prepared aspirate and an intact core with evaluable marrow. It supports a particle-based differential, a bounded cellularity estimate, a core-based megakaryocyte survey, and an iron stain read only after the positive control performed correctly. It does not support a disease-defining classification. An abnormal-cell concern requires escalation through the laboratory's review and correlation process rather than independent diagnostic labeling in this introductory workflow.

Correlate aspirate cytology, core histology, peripheral blood findings, and available ancillary studies in one integrated interpretation when both marrow components are available. The laboratory method measures selected material and stains, while clinical meaning comes from that correlation. Published M:E and cellularity reference approaches vary, so use the stated laboratory reference range and local criteria. If the preparation is limited, say how it is limited.

Local policy controls acceptance thresholds, report wording for failed criteria, core fixative and processing, personnel authorization, low-count differential qualification, and turnaround time. CLIA requires that policies exist and that a report include condition and disposition when criteria are not met, but it does not provide a marrow-specific numeric threshold. Make the limitation visible, correlate the components, and escalate when the question goes beyond what the material can support.

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