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Module HEME-09 · Version 1.0

Membrane, Fragmentation, and Oxidative Red-Cell Morphology

Identify selected red-cell forms from visible features, standardize a schistocyte estimate, and choose a bounded review action.

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Who this module is for

Medical laboratory scientists and trainees who review peripheral blood smears after HEME-08.

Learning objectives

  • Describe selected red-cell forms against defined feature criteria after distribution and preparation review.
  • Apply explicit inclusion and exclusion criteria to count schistocytes across systematic nonoverlapping fields.
  • Separate a schistocyte percentage report from its bounded review and escalation interpretation.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

14 sources

  1. 1. Palmer L, Briggs C, McFadden S, et al. ICSH recommendations for the standardization of nomenclature and grading of peripheral blood cell morphological features. International Journal of Laboratory Hematology. 2015;37(3):287-303. doi:10.1111/ijlh.12327.

    Source note · consensus standard

  2. 2. Zini G, d'Onofrio G, Erber WN, et al. 2021 update of the 2012 ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. International Journal of Laboratory Hematology. 2021;43(6):1264-1271. doi:10.1111/ijlh.13682.

    Source note · consensus standard

  3. 3. Zini G, d'Onofrio G, Briggs C, et al. ICSH recommendations for identification, diagnostic value, and quantitation of schistocytes. International Journal of Laboratory Hematology. 2012;34(2):107-116. doi:10.1111/j.1751-553X.2011.01380.x.

    Source note · consensus standard

  4. 4. Bolton-Maggs PHB, Langer JC, Iolascon A, Tittensor P, King MJ. Guidelines for the diagnosis and management of hereditary spherocytosis, 2011 update. British Journal of Haematology. 2012;156(1):37-49. doi:10.1111/j.1365-2141.2011.08921.x.

    Source note · professional society guidance

  5. 5. Jilani TN, Schmitz J, Goyal A. Hereditary Elliptocytosis. StatPearls. Updated 2024.

    Source note · peer-reviewed literature

  6. 6. American Society of Hematology Image Bank. Target cells.

    Source note · professional society guidance

  7. 7. Riaz H, McCarthy M. Acanthocytosis. StatPearls. Updated 2023.

    Source note · peer-reviewed literature

  8. 8. Merck Manual Professional Edition. Myelophthisic Anemia. Reviewed 2024.

    Source note · peer-reviewed literature

  9. 9. Luzzatto L, Nannelli C, Notaro R. Glucose-6-Phosphate Dehydrogenase Deficiency. GeneReviews. Updated 2024.

    Source note · peer-reviewed literature

  10. 10. Merck Manual Professional Edition. Disseminated Intravascular Coagulation. Reviewed 2024.

    Source note · peer-reviewed literature

  11. 11. Zheng XL, Vesely SK, Cataland SR, et al. ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis. 2020;18(10):2486-2495. doi:10.1111/jth.15010.

    Source note · professional society guidance

  12. 12. 42 CFR 493.1291, Standard: Test report. Electronic Code of Federal Regulations, current edition.

    Source note · federal regulation

  13. 13. 42 CFR 493.1445, Standard: Laboratory director responsibilities. Electronic Code of Federal Regulations, current edition.

    Source note · federal regulation

  14. 14. College of American Pathologists. Hematology Checklist, HEM.34600, Criteria for Blood Film Review, 2020 edition.

    Source note · accreditation standard