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Module HEME-17 · Version 1.0

Alpha- and Beta-Thalassemia Patterns

Use CBC indices, smear findings, hemoglobin fractions, age, iron status, and bounded follow-up to recognize thalassemia patterns without assigning genotype from one result.

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Who this module is for

Medical laboratory scientists and hematology staff who review microcytic CBC and hemoglobin fractionation patterns.

Learning objectives

  • Differentiate trait, intermedia-pattern, and major-pattern concepts without relying on one index.
  • Interpret HbA2 and HbF in age, iron status, transfusion, and method context.
  • Recognize alpha-thalassemia patterns that may have normal adult hemoglobin analysis and select bounded molecular or family correlation when justified.

How completion works

Mark every required section done and answer every knowledge check in those sections correctly. The final save completes the module automatically.

Sources

10 sources

  1. 1. Tamary H, Greenberg-Kushnir N, Dgany O. Alpha-Thalassemia. GeneReviews [Internet]. University of Washington, Seattle; updated 2026-04-23. https://www.ncbi.nlm.nih.gov/books/NBK1435/

    Source note · professional society guidance

  2. 2. Langer AL. Beta-Thalassemia. GeneReviews [Internet]. University of Washington, Seattle; revised 2026-02-12. https://www.ncbi.nlm.nih.gov/books/NBK1426/

    Source note · professional society guidance

  3. 3. Galanello R, Origa R. Screening and diagnosis for haemoglobin disorders. NCBI Bookshelf; 2013. https://www.ncbi.nlm.nih.gov/books/NBK190467/

    Source note · laboratory reference

  4. 4. Centers for Disease Control and Prevention. Hemoglobinopathies: Current Practices for Screening, Confirmation and Follow-up. 2024. https://www.cdc.gov/sickle-cell/media/fact-sheets/best-practices/hemoglobinopathies-current-practices-nbs.pdf

    Source note · federal guidance

  5. 5. Centers for Disease Control and Prevention. Newborn Screening for Hemoglobinopathies. https://www.cdc.gov/sickle-cell/testing/newborn-screening.html

    Source note · federal guidance

  6. 6. International Council for Standardization in Haematology. Recommendations for the assessment of equipment for the quantitation of HbA2. Int J Lab Hematol. 2019;41:21-26.

    Source note · consensus standard

  7. 7. Centers for Medicare & Medicaid Services. 42 CFR 493.1253, establishment and verification of performance specifications. https://www.ecfr.gov/current/title-42/chapter-IV/subchapter-G/part-493/subpart-K/section-493.1253

    Source note · federal regulation

  8. 8. Centers for Medicare & Medicaid Services. 42 CFR 493.1255, maintenance and operation of equipment. https://www.ecfr.gov/current/title-42/chapter-IV/subchapter-G/part-493/subpart-K/section-493.1255

    Source note · federal regulation

  9. 9. College of American Pathologists. All Common Checklist, current laboratory accreditation edition. https://documents.cap.org/documents/all-common-checklist.pdf

    Source note · accreditation standard

  10. 10. Clinical and Laboratory Standards Institute. Hemoglobinopathy testing and newborn-screening documents, official catalog. https://clsi.org/standards-development/

    Source note · consensus standard