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Section 1 of 6 · Open sections

Required section · Section 1 of 6

Opening laboratory problem

An adult EDTA whole-blood specimen has a microcytic, hypochromic CBC pattern. The compact result table records the measured CBC evidence before any pattern assignment.

The peripheral smear shows marked microcytosis, hypochromia, target cells, and mild anisopoikilocytosis; no nucleated red blood cells are seen. These findings support a microcytic process but do not establish a specific disorder. Basophilic stippling, if present, is also nonspecific and requires smear and exposure correlation.

Microcytosis and hypochromia with a relatively preserved or increased RBC count support a thalassemia carrier pattern, but iron deficiency remains a competing explanation until iron status is assessed. A fractionation pattern is not a genotype: assemble CBC, smear, iron, age, and fractionation evidence before releasing an interpretation.

Opening CBC results. Intervals are local illustrative values.
TestResultLocal illustrative intervalObserved pattern
Hemoglobin11.2 g/dL12.0-16.0 g/dLLow
RBC count5.62 × 10^12/L3.80-5.20 × 10^12/LRelatively increased
MCV63.0 fL80-100 fLMicrocytosis
MCH19.9 pg27-33 pgHypochromia

Knowledge checks

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Knowledge check 1

Which finding most supports keeping a thalassemia carrier pattern in the differential for the opening CBC?

Choose one option.

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